Erratum to: Analysis of conditional gene deletion using probe based Real-Time PCR
نویسندگان
چکیده
منابع مشابه
Analysis of conditional gene deletion using probe based Real-Time PCR
BACKGROUND Conditional gene deletion using Cre-lox recombination is frequently used in mouse genetics; however recombination is frequently incomplete, resulting in a mixture of cells containing the functional (2lox) allele and the truncated (1lox) allele. Conventional analysis of 1lox/2lox allele ratios using Southern Blotting is time consuming, requires relatively large amounts of DNA and has ...
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spinal muscular atrophy (sma) is a common autosomal recessive neuromuscular disorder caused by the loss of α-motor neurons in the spinal cord. the survival motor neuron (smn) protein is encoded by 2 genes, smn1 and smn2. the most frequent mutation is the biallelic deletion of exon 7 of the smn1 gene. smn2 cannot compensate for the loss of smn1, due to the exclusion of exon 7. carrier frequency ...
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ژورنال
عنوان ژورنال: BMC Biotechnology
سال: 2010
ISSN: 1472-6750
DOI: 10.1186/1472-6750-10-90